Teaching NeuroImages: 5-FU-induced acute leukoencephalopathy
نویسندگان
چکیده
منابع مشابه
Teaching NeuroImages: 5-FU-induced acute leukoencephalopathy.
A 55-year-old man with carcinoma sigmoid colon (fluorouracil [5-FU]: cumulative dose of 6,600 mg/m; and oxaliplatinum: 245 mg/m) presented with encephalopathy and pancerebellar involvement 2 weeks after receiving a third cycle of chemotherapy. Brain MRI showed diffusion restriction in bilateral deep white matter, cerebellar peduncles, and splenium of corpus callosum (figures 1 and 2) suggestive...
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This is a 57-year-old right-handed male with a history of locally advanced esophageal adenocarcinoma, who presented with confusion and speech changes. Patient received 5-Fluorouracil (5-FU) and cisplatin four days prior to presentation, which was complicated by very poor oral intake on day 2 of therapy. On the day of presentation, he was confused and his speech was slurred. The remainder of the...
متن کامل5-FU induced acute toxic leukoencephalopathy: early recognition and reversibility on DWI-MRI.
Acute toxic leukoencephalopathy (ATL) is a rare adverse effect of 5-Fluorouracil (5-FU) chemotherapeutic agent. It is imperative for the radiologist to confidently identify the white matter changes caused by this agent in case of toxicity. This will help in early detection and appropriate management of patient, as the condition is reversible both clinically and on imaging. We report a case of a...
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A 52-year-old man with recently diagnosed HIV infection (CD4 count 105/mL; normal range 700– 1,200/mL) presented with a 5-week history of irregular shaking of his left hand triggered by lifting his arm accompanied by “feeling of stiffness and clumsiness.” On clinical examination, focal myoclonus with positive and negative components affecting the left upper limb with distal predominance was det...
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ژورنال
عنوان ژورنال: Neurology
سال: 2013
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0b013e3182904d03